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. 2019 Mar 28;10:278. doi: 10.3389/fgene.2019.00278

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Copyright © 2019 Zhang, Duan, Cun and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination and analysis of the prognostic AS signatures in BRCA cohort. BRCA patients were divided into high- and low-risk subgroups based on the median cut of risk score calculated separately. The upper part of each assembly indicates distribution of patients’ survival status and survival times ranked by risk score, the middle part represents the risk score curve, and the bottom heatmap displays splicing pattern of the AS signature from each AS type or all seven AS types. Color transition from blue to red indicates the increasing PSI score of corresponding AS event from low to high. (A–G) Risk score (corresponding to each AS type) calculated and AS signature constructed using each AS type of prognostic splicing events. (H) Risk score (all) calculated and final AS signature constructed using all types of prognostic splicing events.