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. 2019 Mar 28;10:278. doi: 10.3389/fgene.2019.00278

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Copyright © 2019 Zhang, Duan, Cun and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROC curves with calculated AUCs of prognostic signatures built by either one type or all seven AS types in BRCA cohort for risk prediction in 3 years. (A) 5 years (B) and 8 years (C), respectively. (D) The curves of time-dependent AUCs versus time (3–8 years) of either each or final signature: AUC(t) versus t. (E) The curve of the difference of time-dependent AUCs between final and RI signature over time (3–8 years): AUC(t) versus t. The color dashed bands indicated the pointwise 95% confidence intervals of estimated AUCs difference. The dashed line evaluates whether the difference of two estimated AUCs at each timepoint is statistical significance.

Inline graphic — ROC curves with calculated AUCs of prognostic signatures built by either one type or all seven AS types in BRCA cohort for risk prediction in 3 years. (A) 5 years (B) and 8 years (C), respectively. (D) The curves of time-dependent AUCs versus time (3–8 years) of either each or final signature: AUC(t) versus t. (E) The curve of the difference of time-dependent AUCs between final and RI signature over time (3–8 years): AUC(t) versus t. The color dashed bands indicated the pointwise 95% confidence intervals of estimated AUCs difference. The dashed line evaluates whether the difference of two estimated AUCs at each timepoint is statistical significance.