Table 1.
Detailed information of specific AS events involved in each AS signature and final prognostic model.
| AS events | Gene symbol | Splice type | Exons | From exon | To exon | P-value | Hazard ratio | 95% Confidence interval | 20-AS-event-based classifier |
|---|---|---|---|---|---|---|---|---|---|
| AA_CARM1_ID_47598 | CARM1 | AA | 16.1:16.2 | 15 | 16.3 | 0.000498 | 0.269 | 0.128–0.563 | |
| AA_ZBTB25_ID_27884 | ZBTB25 | AA | 7.1 | 6 | 7.2 | 0.000596 | 0.3 | 0.151–0.596 | |
| AA_GPBP1_ID_72126 | GPBP1 | AA | 12.1 | 11 | 12.2 | 0.000859 | 0.325 | 0.168–0.629 | |
| AA_ZNRF1_ID_37578 | ZNRF1 | AA | 6.1 | 5 | 6.2 | 0.00228 | 2.8 | 1.45–5.43 | ∗ |
| AA_DDX41_ID_74796 | DDX41 | AA | 7.1 | 6 | 7.2 | 0.00388 | 0.392 | 0.207–0.74 | |
| AA_CTDSP1_ID_57478 | CTDSP1 | AA | 4.1 | 3 | 4.2 | 0.00441 | 0.386 | 0.201–0.744 | |
| AD_OS9_ID_22701 | OS9 | AD | 5.2:5.3 | 5.1 | 6 | 0.00235 | 2.7 | 1.42–5.13 | ∗ |
| AD_HN1_ID_43371 | HN1 | AD | 5.2 | 5.1 | 6 | 0.00427 | 0.388 | 0.203–0.743 | |
| AD_THTPA_ID_26757 | THTPA | AD | 1.5 | 1.4 | 2 | 0.00511 | 0.377 | 0.19–0.746 | ∗ |
| AD_NTMT1_ID_87866 | NTMT1 | AD | 5.2 | 5.1 | 6 | 0.00556 | 0.395 | 0.205–0.761 | ∗ |
| AD_MGME1_ID_58753 | MGME1 | AD | 2.2 | 2.1 | 3 | 0.00625 | 0.415 | 0.221–0.779 | ∗ |
| AD_SEC31A_ID_69735 | SEC31A | AD | 10.2 | 10.1 | 11 | 0.00879 | 0.424 | 0.223–0.806 | |
| AP_SEC22A_ID_66462 | SEC22A | AP | 2.1 | 0.000205 | 0.258 | 0.126–0.527 | |||
| AP_ALG3_ID_67851 | ALG3 | AP | 2.1 | 0.00032 | 0.277 | 0.138–0.558 | ∗ | ||
| AP_PACS2_ID_29630 | PACS2 | AP | 2 | 0.000733 | 3.2 | 1.63–6.28 | |||
| AP_ECE2_ID_67857 | ECE2 | AP | 4 | 0.00103 | 4.45 | 1.83–10.8 | ∗ | ||
| AP_HSP90AB1_ID_76378 | HSP90AB1 | AP | 2 | 0.00182 | 0.347 | 0.179–0.675 | |||
| AT_MAGT1_ID_89535 | MAGT1 | AT | 11 | 0.000186 | 3.74 | 1.87–7.47 | ∗ | ||
| AT_RCBTB1_ID_25898 | RCBTB1 | AT | 14 | 0.000294 | 3.46 | 1.77–6.78 | ∗ | ||
| AT_SIN3B_ID_48214 | SIN3B | AT | 8.2 | 0.000508 | 3.41 | 1.71–6.8 | |||
| AT_SARNP_ID_22252 | SARNP | AT | 10.2 | 0.00053 | 0.297 | 0.149–0.59 | |||
| AT_ZNF675_ID_48822 | ZNF675 | AT | 4 | 0.000571 | 0.275 | 0.132–0.574 | |||
| AT_STOX2_ID_71289 | STOX2 | AT | 4 | 0.00067 | 5.28 | 2.02–13.8 | ∗ | ||
| AT_NIPAL3_ID_1110 | NIPAL3 | AT | 9 | 0.000837 | 0.33 | 0.172–0.633 | ∗ | ||
| ES_NDUFA12_ID_23737 | NDUFA12 | ES | 3 | 2.2 | 5.1 | 0.000239 | 0.248 | 0.118–0.522 | ∗ |
| ES_UBR4_ID_880 | UBR4 | ES | 105 | 104 | 106 | 0.00041 | 0.271 | 0.131–0.559 | ∗ |
| ES_COPS3_ID_39468 | COPS3 | ES | 9 | 8 | 10 | 0.000502 | 0.283 | 0.139–0.576 | ∗ |
| ES_ABCE1_ID_70753 | ABCE1 | ES | 14 | 13 | 15 | 0.000691 | 0.312 | 0.159–0.612 | |
| ES_CCNI_ID_69628 | CCNI | ES | 2 | 1 | 3 | 0.000697 | 0.316 | 0.162–0.615 | |
| ES_RPAP1_ID_30096 | RPAP1 | ES | 22.2:23.1 | 22.1 | 23.2 | 0.000787 | 0.3 | 0.149–0.606 | ∗ |
| ME_HLCS_ID_96019 | HLCS | ME | 4| 5 | 3 | 6 | 0.00111 | 0.338 | 0.176–0.649 | ∗ |
| RI_RBM48_ID_80441 | RBM48 | RI | 4.2 | 4.1 | 4.3 | 0.000128 | 0.235 | 0.112–0.493 | |
| RI_RBM6_ID_64936 | RBM6 | RI | 14.2 | 14.1 | 14.3 | 0.000144 | 0.263 | 0.132–0.524 | |
| RI_RPAP1_ID_30095 | RPAP1 | RI | 23.3 | 23.2 | 23.4 | 0.000599 | 0.279 | 0.135–0.578 | ∗ |
| RI_METTL17_ID_26476 | METTL17 | RI | 9.2 | 9.1 | 9.3 | 0.000622 | 0.298 | 0.149–0.596 | |
| RI_POMGNT1_ID_2787 | POMGNT1 | RI | 12.2 | 12.1 | 12.3 | 0.00122 | 0.333 | 0.171–0.648 | ∗ |
| RI_TRABD_ID_62792 | TRABD | RI | 11.2 | 11.1 | 11.3 | 0.0015 | 2.84 | 1.49–5.42 | ∗ |
| RI_WDR6_ID_64794 | WDR6 | RI | 4.5 | 4.4 | 4.6 | 0.00155 | 0.34 | 0.174–0.663 | ∗ |
| RI_FASTK_ID_82335 | FASTK | RI | 5.4 | 5.3 | 5.5 | 0.00194 | 0.334 | 0.167–0.668 | |
| RI_NAA38_ID_81579 | NAA38 | RI | 1.2 | 1.1 | 1.3 | 0.00199 | 0.349 | 0.179–0.68 |
∗Indicates AS events included in the final prognostic model.