Table 2.
Univariate cox proportional hazard analysis of clinicopathologic variable influence in BRCA cohort.
| Features | Events (N = 645) | Crude HR (95% CI) | Log-rank P |
|---|---|---|---|
| Age | 0.0414 | ||
| <60 | 370 | ||
| ≥60 | 275 | 1.8635 (1.025–3.389) | |
| Histological type | 0.1∗ | ||
| Infiltrating ductal carcinoma | 456 | 1 | |
| Infiltrating lobular carcinoma | 130 | 0.3708 (0.1302–1.056) | |
| Other | 59 | 1.1786 (0.4903–2.833) | |
| PR | 0.204 | ||
| Negative | 210 | 1 | |
| Positive | 435 | 0.6737 (0.3664–1.239) | |
| ER | 0.0362∗ | ||
| Negative | 144 | 1 | |
| Positive | 501 | 0.5152 (0.277–0.9582) | |
| Her2 | 0.267 | ||
| Negative | 538 | 1 | |
| Positive | 107 | 1.4987 (0.734–3.06) | |
| Positive lymph nodes | 0.002∗ | ||
| 0 | 329 | 1 | |
| 1∼3 | 210 | 1.590 (0.7813–3.234) | |
| > 3 | 106 | 3.511 (1.6670–7.397) | |
| Pathology stage | 0.0005∗ | ||
| Stage I and II | 501 | 1 | |
| Stage III and IV | 144 | 2.889 (1.551–5.381) | |
| T | 0.6 | ||
| T1 | 186 | 1 | |
| T2 | 362 | 0.8604 (0.4333–1.708) | |
| T3 and 4 | 97 | 1.3287 (0.5479–3.222) | |
| N | 0.0005∗ | ||
| N0 | 318 | 1 | |
| N1 | 220 | 1.430 (0.7152–2.859) | |
| N2 | 68 | 1.982 (0.7659–5.126) | |
| N3 | 39 | 7.042 (2.5056–19.791) | |
| 20-AS event-based classifier | 0.0000000000008∗ | ||
| Low | 323 | 1 | |
| High | 322 | 58.910 (8.052–431) |
ER, estrogen receptor; PR, progesterone receptor; Her-2, human epidermal growth factor 2.