. 2019 Mar 28;10:290. doi: 10.3389/fneur.2019.00290

Table 2.

Summary ORs and 95% CI of ALDH2 polymorphisms and AD and PD risk.

	N*	OR	95% CI	P	I²(%)	OR	95% CI	P	I²(%)	OR	95% CI	P	I²(%)	OR	95% CI	P	I²(%)	OR	95% CI	P	I²(%)
rs671		A vs. G				GA vs. GG				AA vs. GG				GA+AA vs. GG				AA vs. GG+GA
AD Total	6	1.46	1.01–2.11	0.05	84.2	1.35	0.91–1.99	0.13	73.9	2.22	1.03–4.77	0.04	79.2	1.36	0.90–2.03	0.14	81.0	1.94	1.03–3.64	0.04	71.1
HWE–yes	4	1.48	0.88–2.49	0.14	87.4	1.26	0.72–2.21	0.41	79.4	2.57	1.01–6.53	0.05	78.1	1.45	0.77–2.73	0.25	86.0	2.23	1.18–4.60	0.01	61.4
HWE–no	2	1.36	1.10–1.69	0.01	NA	1.60	1.21–2.12	0.001	NA	1.33	0.78–2.27	0.29	NA	1.19	0.64–2.18	0.58	76.4	1.11	0.66–1.87	0.69	NA
COUNTRY
China	3	1.64	0.87–3.10	0.12	88.3	1.39	0.67–2.85	0.38	83.0	3.15	1.03–9.65	0.04	79.6	1.63	0.74–3.62	0.23	87.9	2.75	1.23–6.14	0.02	63.0
Japan	2	1.54	1.00–2.36	0.05	17.1	1.28	0.77–2.13	0.33	69.7	1.34	0.85–2.12	0.20	0	1.31	0.87–1.98	0.20	59.6	1.18	0.76–1.85	0.46	0
CONTROL DESIGN
HB	4	1.57	1.02–2.42	0.04	86.0	1.47	0.95–2.27	0.09	74.6	2.48	0.98–6.30	0.06	83.4	1.63	0.99–2.67	0.05	82.7	2.10	0.96–357	0.06	77.6
PB	2	1.07	0.75–1.54	0.71	NA	0.95	0.58–1.55	0.84	NA	1.38	0.57–3.35	0.48	NA	0.93	0.65–1.32	0.68	0	1.41	0.60–3.34	0.43	NA
SUBJECTS
>500	2	1.36	1.10–1.69	0.01	NA	1.60	1.21–2.12	0.001	NA	1.33	0.78–2.27	0.29	NA	1.19	0.64–2.18	0.58	76.4	1.11	0.66–1.87	0.69	NA
< 500	4	1.48	0.88–2.49	0.14	87.4	1.26	0.72–2.21	0.41	79.4	2.57	1.01–6.53	0.05	78.1	1.45	0.77–2.73	0.25	86.0	2.23	1.18–4.60	0.01	61.4
NOS EVALUATION
NOS < 8	5	1.57	1.02–2.42	0.04	86.0	1.47	0.95–2.27	0.09	74.6	2.48	0.98–6.30	0.06	83.4	1.43	0.90–2.28 .92–2.18	0.13	82.9	2.10	0.96–357	0.06	77.6
NOS ≥8	1	1.07	0.75–1.54	0.71	NA	0.95	0.58–1.55	0.84	NA	1.38	0.57–3.35	0.748	NA	1.01	0.64–1.61	0.96	NA	1.41	0.60–3.34	0.43	NA
GENDER
Male	2	1.52	1.06–2.16	0.02	0	1.70	1.07–2.70	0.03	14.3	1.81	0.73–4.46	0.20	0	1.72	1.10–2.67	0.02	0	1.47	0.60–3.58	0.40	0
Female	2	0.90	0.40–2.10	0.79	83.4	0.94	0.35–2.57	0.891	81.5	0.93	0.37–2.32	0.88	43.8	0.91	0.33–1.2.49	0.86	84.3	0.98	0.57–1.69	0.95	0
PD Total	2	1.38	0.77–2.45	0.28	85.2	1.23	0.98–1.52	0.07	0	1.95	0.31–12.23	0.47	89.3	1.30	0.90–1.92	0.15	53.6	1.18	0.29–11.16	0.52	89.4
Rs4767944		T vs. C				CT vs. CC				TT vs. CC				CT+TT vs. CC				TT vs. CC+CT
PD Total	2	0.87	0.67–1.14	0.31	70.9	0.89	0.58–1.36	0.60	71.3	0.57	0.40–0.80	< 0.01	0	0.83	0.51–1.36	0.46	80.3	0.71	0.56–0.90	0.01	0