. 2019 Apr 1;14:2267–2280. doi: 10.2147/IJN.S194934

Table 4.

Pharmacokinetic parameters of the three formulations (n=6)

Parameters	Formulations
	GPS powder	GPS-NLCs	GPS-SGC-NLCs

T_max (h)	0.792±0.102	1.417±0.276^*	2.250±0.212^^,^*
C_max (µg/mL)	0.455±0.080	0.671±0.073^*	0.859±0.113^^,^*
AUC_0–_∞ (µg/mL·h)	1.355±0.407	4.591±0.668^*	11.491±0.707^^,^*
MRT_0–_∞ (h)	6.224±0.341	11.832±1.413	21.589±1.267^^,^*

Notes:

P<0.05, vs GPS powder.

^**

P<0.05, vs GPS NLCs. Data are represented as mean ± SD.

Abbreviations: GPS, gypenosides; SGC, sodium glycocholate; NLCs, nanostructured lipid carriers. T_max, time peak plasma concentration; C_max, peak plasma concentration; AUC_0–_∞, area under the plasma concentration time curve; MRT_0–_∞, mean retention time.