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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Hypertension. 2019 Apr;73(4):849–858. doi: 10.1161/HYPERTENSIONAHA.118.12198

Figure 5: WD induces peri-arteriolar fibrosis, collagen accumulation and interstitial fibrosis dependent on the ECMR.

Figure 5:

A. Quantification of peri-arteriolar and interstitial fibrosis with representative images to the right (peri-arteriolar, top panel; interstitial fibrosis, bottom panel). Note the peri-arteriolar fibrosis extending into the interstitium (top middle panel). N=5 for CD ECMR+/+, 6 for WD ECMR+/+ and 6 for WD ECMR −/−. B. Western blot analysis of collagen 1 and collagen 3 expression normalized to GAPDH with quantification below. N=4 for CD ECMR+/+, 5 for WD ECMR+/+ and 5 for WD ECMR−/−. Kidney tissue from upper pole was used for immunostaining. Kidney tissue from lower pole was used for western blots. Control diet (CD), Western Diet (WD). Data are expressed as means ± SEM. † P<0.05 vs CD; ‡ p<0.05 vs WD ECMR+/+.