Table 1.
Brucella T4SS effectors
| Name | ORF in B. abortus | Host target | Function | References |
|---|---|---|---|---|
| RicA | BAB1_1279 | Rab2 | modulates rBCV biogenesis | (28) |
| VceA | BAB1_1652 | unknown | unknown | (27) |
| VceC | BAB1_1058 | Grp78/BiP | UPR activation | (27, 42) |
| BspA | BAB1_0678 | unknown | intracellular replication | (30) |
| BspB | BAB1_0712 | COG | redirects Golgi vesicular traffic; rBCV biogenesis; intracellular replication | (30, 38) |
| BspC | BAB1_0847 | unknown | unknown | (30) |
| BspE | BAB1_1675 | unknown | unknown | (30) |
| BspF | BAB1_1948 | unknown | intracellular replication | (30) |
| BtpA/TcpB | BAB1_0279 | MAL | Inhibition of TLR signaling; UPR induction | (52) |
| BtpB | BAB1_0756 | unknown | unknown | (31) |
| SepA | BAB1_1492 | unknown | eBCV trafficking | (32) |
| BPE005 | BAB1_2005 | unknown | Unknown | (29) |
| BPE043 | BAB1_1043 | unknown | Unknown | (29) |
| BPE275 | BAB1_1275 | unknown | Unknown | (29) |
| BPE123 | BAB1_0123 | unknown | Unknown | (29) |