Table 1.
HBV DNA and HBsAg Levels in Different Settings1
| Response | HBV DNA | HBsAg | References |
|---|---|---|---|
| Natural history | |||
| Inactive hepatitis | <2,000 IU/mL | <1,000 IU/mL | 6 |
| Low risk of HCC | <2,000 IU/mL | <1,000 IU/mL | 8 |
| Treatment response to PEG‐IFN | |||
| HBeAg‐positive | |||
| Good | <20,000 IU/mL at week 24 | <1,500 IU/mL at week 24 | 9 |
| Poor | High, no clear cutoff | >20,000 IU/mL at week 24 | 10, 11 |
| High, no clear cutoff | No decline at week 12 or 24 | 12 | |
| HBeAg‐negative | |||
| Good | Unclear | >1 log decline at week 48 | 13 |
| Unclear | >10% decline at week 24 | 14 | |
| Poor | ≤2 log decline at week 12 | No decline at week 12 | 15 |