Table 1.

Systemic Hemodynamic and Neurohormonal Parameters in Patients With Nonazotemic Cirrhosis and Ascites Who Did or Did Not Develop Type 2 HRS During Follow‐Up3

Parameter	Baseline Data for Patients Not Developing Type 2 HRS (n = 39)	Data for Patients Developing Type 2 HRS (n = 15)
		Baseline	Type 2 HRS
Mean arterial pressure (mm Hg)	88 ± 9	86 ± 10	79 ± 7
PRA (ng/mL·hour−1)	3.1 ± 2.3	7.5 ± 3.7	11.9 ± 4.8
NE (pg/mL)	222 ± 68	442 ± 155	629 ± 320
Systemic vascular resistance (dyn·s/cm−5)	962 ± 256	1032 ± 251	1014 ± 276
Cardiac output (L/minute)	7.2 ± 1.8	6.2 ± 1.4	5.8 ± 1.2
Heart rate (bpm)	87 ± 15	84 ± 12	80 ± 14

These results are indicative of a progressive deterioration of cardiocirculatory function. The absence of significant changes in systemic vascular resistance between the groups is compatible with peripheral arterial vasodilatation compensated by the vasoconstrictor effect of the RAAS and the SNS. The lack of an increase in the heart rate indicates an impairment in cardiac chronotropic function. HRS developed in patients with severe impairment of systemic hemodynamics. The data are presented as means and standard deviations.