Table 2:
KB220 Variants and Relapse Rates Compared to Controls in Reward Deficiency Syndrome (RDS)
| Patient Category | KB220 Re lapse Rate (N) (%) |
Controls Relapse Rate (N) (%) |
Reference | Experimental Length of time |
|---|---|---|---|---|
| Out-Patient Alcohol | 15 (26) | 15 (87) | Brown et al1 | Ten months |
| Out-Patient Cocaine | 15 (47) | 15 (93) | Brown et al1 | Ten months |
| In-Patient Opioids Detox | 29 (18) | NA | Blum et al2 | Four months |
| Out-patient Alcohol | 61 (7) | NA | Chen et al3 | 12 months |
| Out-patient Heroin | 4 (0) | NA | Chen et al3 | 12 months |
| Out-patient Alcohol | 23 (22) | NA | Miller et al4 | 12 months |
| Out-patient Alcoholics | 21 (30) | NA | Miller et al4 | 24 months |
| Out-patient Alcohol | 600 (0) | NA | Blum et al5 | 3 months** |
| Out-patient Bariatric | 16 (18.2) | 11 (82.2) | Blum et al6 | 3 months |
| Out-patient Bariatric | 130 (14,7) | 117 (41.7) | Blum et al.7 | 24 months |
| Average RDS | 91.4 (18.29) | 158 (76)* | NA | 11.4 |
Note: Approximately 90% of alcoholics experience at least one relapse in the four years following treatment. Similar relapse rates occur for recovering smokers and heroin addicts, suggesting that many addictive behaviors may share the same behavioral, biochemical, and cognitive components. Like alcoholism, opiate addiction exhibits high relapse rates - the research shows more than 80 percent among those who receive behavioral treatments as a sole treatment. In an important study cited by Reuters, 48 percent of meth users who followed detox with drug rehab were still sober after three months; and 20 percent of those who attended treatment were still abstinent after one year, in contrast to only 7 percent of people who had undergone detox alone or received no treatment.
While Blum’s group and others have reported on relapse rates using data from NIDA/NIAAA this current number of 76% is well within the relapse percentages seen across the entire scientific literature in the addiction space [8].
The evaluation took place from 2000 to 2005 so that concerning relapse the total DATA tabulated from an extensive database and each subject’s duration of relapse was grouped. However, it is noted that the minimum criteria to enter into the study was a receipt of an at least 3-month supply of oral KB220 and as such, we considered only to be three months a very truncated effect.