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. Author manuscript; available in PMC: 2019 Apr 4.
Published in final edited form as: Biotarget. 2017 Dec 13;1:18. doi: 10.21037/biotarget.2017.12.01

Figure 4.

Figure 4

Small molecules that bind V-ATPase subunits and prevent their inter-enzyme interaction with other subunits were identified in an effort to selectively inhibit V-ATPases in osteoclasts. The schematic depicts small molecule inhibitors of (A) a3–d2 and (B) a3–B2 interactions. V-ATPases, vacuolar H+-ATPases; PRR, (pro) renin receptor.