Table 2. Levels of inflammatory biomarkers, by HIV serostatus.
|
Biomarker |
Cut point for Upper Quintile | HIV-uninfected (n = 276) Median (IQR) | HIV-infected (n = 452) Median (IQR) | Unadjusted p value |
Adjusted* p value |
|---|---|---|---|---|---|
| sCD163 (ng/ml) | >873 | 554 (449, 696) | 679 (519, 876) | <0.001 | <0.001 |
| sCD14 (ng/ml) | >1,810 | 1,292 (1,130, 1,458) | 1,615 (1,393, 1,895) | <0.001 | <0.001 |
| ICAM-1 (ng/ml) | >315 | 228 (192, 270) | 258 (215, 314) | <0.001 | 0.04 |
| CCL2 (pg/ml) | >354 | 235 (183, 313) | 273 (211, 350) | <0.001 | <0.001 |
| CRP (ug/ml) | >3.2 | 1.0 (0.54, 1.98) | 1.3 (0.7, 2.8) | 0.01 | <0.01 |
| IL-6 (pg/ml) | >2.7 | 1.3 (0.89, 2.17) | 1.5 (1.0, 2.4) | 0.01 | 0.01 |
| sTNF-αR1 (pg/ml) | >1,516 | 1,165 (956, 1,354) | 1,167 (950, 1,463) | 0.04 | 0.06 |
| sTNF-αR2 (pg/ml) | >8,188 | 5,905 (4,961, 6,949) | 6,575 (5,436, 8,017) | <0.001 | <0.001 |
| Fibrinogen (ml/dl) | >391 | 336 (294, 380) | 326 (282, 377) | 0.07 | 0.11 |
| D-dimer (ug/ml) | >0.4 | 0.2 (0.13, 0.30) | 0.3 (0.1, 0.3) | 0.14 | 0.99 |
Abbreviations: IQR, interquartile range; sCD163, soluble cluster of differentiation 163; sCD14, soluble cluster of differentiation 14; CCL2, chemokine (C-C motif) ligand 2; ICAM-1, intercellular cell adhesion molecule-1; CRP, C reactive protein; IL-6, interleukin-6; sTNF-αR1, soluble tumor necrosis factor-alpha receptor 1; sTNF-αR2, soluble tumor necrosis factor-alpha receptor 2.
Unadjusted p values were obtained using the Wilcoxon rank sum test.
*Adjusted p values were obtained from Wald tests from multivariable linear regression models that adjusted for age, race/ethnicity, baseline education, study center, enrollment in the MACS cohort (pre- and post-2001), systolic blood pressure, body mass index, total cholesterol, high-density lipoprotein (HDL) cholesterol, alcohol consumption since last visit, smoking status with cumulative pack year use, hepatitis C infection, and use of medication for hypertension, diabetes and high cholesterol.