Table 4. Stability of dacomitinib (DMB) under different storage conditions.

Nominal Concentrations of DMB in ng/mL	Meana	SD	RSD %	Accuracy %
Room Temp. for 8 hr
2	1.87	0.06	3.28	93.59
15	14.72	0.34	2.34	97.30
150	147.46	1.35	0.92	98.31
400	393.12	3.52	0.90	97.72
Three freeze-thaw cycles
2	1.82	0.04	2.45	91.10
15	14.29	0.09	0.62	95.29
150	144.21	4.88	3.39	96.14
400	385.87	2.68	0.69	96.47
Sored at 4 °C for 24 hr
2	1.83	0.03	1.57	91.47
15	14.22	0.23	1.64	94.77
150	145.71	2.46	1.69	97.14
400	387.12	4.08	1.05	96.78
Sored at -20 °C for 30 days
2	1.80	0.06	3.56	89.98
15	14.39	0.57	3.98	95.95
150	148.21	1.85	1.25	98.81
400	392.37	4.14	1.05	98.09

^a Average of six replicates