Table 5. Metabolic stability parameters for DMB incubation with RLMs.
OTB metabolic stability parameters | |
---|---|
Parameter | Value |
Regression equation a | y = -0.0044x + 4.6048 |
r2 b | 0.9989 |
Slope | 0.0044 |
t1/2 c | 157.5 min |
CLint d | 0.97 mL/min/kg |
a Regression equation of linear portion of curve
b Correlation coefficient
c Half-life
d Intrinsic clearance.