Table 6.
Significant differentially methylated CpGs for fasting glucose replicated in healthy control individuals from the Lifelines type 2 diabetes EWAS subsample (n = 98)
| Illumina ID | CHR | MAPINFO | Gene name | Location in gene | Location in CpG island | Mean methylation (%) | Model 1 | Model 1 + BMI | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Delta methylation (%) | p value | Delta methylation (%) | p value | |||||||
| cg06500161 | 21 | 43656587 | ABCG1 | Body | Shore | 59.1 | 1.82 | 6.8 × 10−3 | 1.68 | 1.6 × 10−3 |
| cg06715330 | 17 | 80158206 | CCDC57 | Body | Open sea | 81.3 | −1.82 | 0.01 | −2.05 | 6.6 × 10−3 |
| cg16809457 | 6 | 90399677 | MDN1 | Body | Open sea | 56.6 | 1.71 | 0.08 | 2.08 | 0.04 |
| cg16097041 | 1 | 154965544 | FLAD1 | 3′UTR | Open sea | 59.4 | 1.27 | 0.09 | 1.61 | 0.04 |
Delta methylation is based on β values; p values are based on M values
Significant p values < 0.05
CHR, chromosome; MAPINFO, position on the chromosome; Shore, 0–2 kb from CpG island; Shelf, 2–4 kb from CpG island; Open sea, more than 4 kb from CpG island