Table 1.
Metabolites significantly (p < 5.8 × 10−5) associated with insulin secretion measured using hyperglycaemic clamps
| Phenotype | Metabolite | β (SE) | p |
|---|---|---|---|
| First-phase GSIS | None | ||
| Second-phase GSIS | PC aa C34:4 | −0.308 (0.073) | 2.46 × 10−5 |
| PC aa C38.5 | −0.023 (0.006) | 3.23 × 10−5 | |
| PC aa C32:1 | −0.027 (0.007) | 3.34 × 10−5 | |
| GLP-1-SIS | PC aa C34:4 | −0.254 (0.060) | 2.12 × 10−5 |
| Arginine-SIS | None | ||
| Disposition index | None | ||
| Insulin sensitivity index | None |
β (SE) and p value were obtained from linear regressions (GEE)
Model: hyperglycaemic clamp phenotype ~ standardised metabolite level + age + sex + BMI + glucose tolerance status + insulin sensitivity (if relevant)