Table 3.
SNPs containing cis eQTLs
| Chr | SNP | Locus for FSI GWAS | eQTLa | FSIb | Lipolysisb | Insulin-stimulated lipogenesisb | WAT morphologyb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect allele | Gene | Effect allele | p value | Effect size | p value | R | p value | R | p value | R | p value | R | |||
| 2 | rs2972143 | Intergenic | G | IRS1 | G | 8.0 × 10−8 | −0.29 | 2.8 × 10−5c | – | 3.4 × 10−4c | + | 3.3 × 10−2 | – | ||
| 4 | rs3822072 | Intronic | A | FAM13A | G | 4.0 × 10−6 | 0.24 | 5.6 × 10−12c | – | 5.6 × 10−7c | – | 1.6 × 10−2 | + | 8.2 × 10−4c | – |
| 6 | rs6912327 | Intronic | T | UHRF1BP1 | C | 2.0 × 10−25 | 0.51 | 1.1 × 10−2 | – | ||||||
| T | SNRPC | C | 3.3 × 10−10 | −0.28 | |||||||||||
| 7 | rs1167800 | Intronicd | A | STAG3L1 | A | 3.3 × 10−10 | −0.28 | ||||||||
| A | TRIM73 | A | 5.2 × 10−8 | −0.34 | 1.5 × 10−2c | – | |||||||||
| A | POM121C | A | 3.6 × 10−7 | −0.22 | 2.0 × 10−2c | – | 3.4 × 10−3c | + | 2.6 × 10−2 | – | |||||
| A | PMS2P3 | A | 6.1 × 10−11 | −0.41 | 8.0 × 10−3 | – | 4.8 × 10−2 | – | |||||||
aSAT eQTL according to GTEx portal
bMicroarray results from the clinical cohort were analysed by regression in QLUCORE, adjusting for array batch, and for WAT morphology, adjusting for age. Only results with p < 0.05 are shown
cFDR <5%
dIntronic in the HIP1 gene
R, regression coefficient, which can be either positive (+) or negative (−)