Figure 3.

Myelin protein transcripts in the periphery are not significantly altered in EAE. A–F, mRNA transcripts of MBP, PMP22, and MPZ were not significantly altered in EAE. G–I, MBP, PMP22, and MOG transcripts were reduced at EAE onset in the dSC suggesting myelinopathy. Normalization of these transcripts was also observed chronically which may indicate repair mechanisms; *,#p < 0.05, one-way ANOVAs with Tukey’s post hoc analysis. A–C, CFA, n = 4; onset, n = 3; chronic, n = 3. D–I, CFA, n = 5; onset, n = 5; chronic, n = 5.