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. 2019 Apr 1;6(2):ENEURO.0400-18.2019. doi: 10.1523/ENEURO.0400-18.2019

Figure 3.

Figure 3.

Vglut2-ires-Cre-mediated recombination of Pomc normalizes body composition. A, Growth curves from male mice. FNΔ2 (red line) mice significantly diverged from both control (blue line) and restored (green line) mice by six weeks of age. B, Growth curves from female mice. FNΔ2 mice significantly diverged from both control and restored mice by five weeks of age. C, D, NMR assessment of body composition. Male (C) and female (D) FNΔ2 mice (red bars) had substantially more body fat than control (blue bars) or restored (green bars) mice, while there were no differences in lean mass. E, F, Weight of gonadal and inguinal fat depots. Male (E) and female (F) FNΔ2 mice (red bars) had substantially larger fat depots (both gonadal and inguinal) than control (blue bars) or restored (green bars) mice. *p < 0.05, **p < 0.01, ****p < 0.001.