Table 1.

Performance of individual metabolite markers and metabolite panel in the validation cohort (Test Set)

Metabolite	AUC (95% CI)	P*	Specificity†, %	Sensitivity‡, %
Indole-derivative§	0.726 (0.631 to 0.822)	<.001	11.3	23.1
LPC(18:0)§	0.842 (0.764 to 0.920)	<.001	26.3	51.3
LPC(20:3)§	0.841 (0.757 to 0.925)	<.001	11.3	48.7
Acetylspermidine	0.755 (0.659 to 0.852)	<.001	27.5	33.3
Diacetylspermine	0.801 (0.712 to 0.890)	<.001	27.5	51.3
5-marker metabolite panel	0.892 (0.828 to 0.996)	<.001	43.3	66.7

^*P values for corresponding area under the curve results, Wilcoxon rank-sum test one-sided. AUC = area under the curve; CI = confidence interval; LPC = lysophosphatidylcholine.

^†% specificity at 95% sensitivity.

^‡% sensitivity at 95% specificity.

^§AUCs <0.5 are flipped (ie, equivalent to 1-AUC due to reverse ordering).