Table 1.
Variable | BRCA1 carriers | BRCA2 carriers |
---|---|---|
N = 14 676 | N = 7912 | |
Case participants, n | 7360 | 4091 |
Year of birth, median (IQR) | 1956 (1948–1964) | 1954 (1945–1961) |
Age at diagnosis, mean (SD), y | 41.1 (9.3) | 44.2 (10.0) |
Control participants, n | 7316 | 3821 |
Year of birth, median (IQR) | 1963 (1953–1972) | 1962 (1950–1971) |
Age at censoring, mean (SD), y | 42.0 (12.5) | 44.0 (13.5) |
Ethnicity, n (%) | ||
Caucasian, not otherwise specified | 13 435 (91.5) | 7126 (90.1) |
Ashkenazi Jewish | 1241 (8.5) | 786 (9.9) |
Height in cm, n | 4502 | 3155 |
Mean (SD) | 164.8 (6.8) | 164.5 (6.9) |
Weight at date of questionnaire in kg, n | 4436 | 3133 |
Mean (SD) | 68.1 (13.9) | 69.0 (14.5) |
BMI at date of questionnaire in kg/m2, n | 4401 | 3115 |
Mean (SD) | 25.1 (5.1) | 25.6 (5.2) |
Weight in early adulthood in kg, n | 3152 | 2296 |
Mean (SD) | 57.6 (9.2) | 57.9 (9.6) |
BMI in early adulthood in kg/m2, n | 3134 | 2283 |
Mean (SD) | 21.2 (3.3) | 21.4 (3.3) |
Age at menarche in years, n | 4425 | 3034 |
Mean (SD), y | 13.0 (1.5) | 13.0 (1.5) |
Parous, n (%) | ||
Yes | 3914 (77.8) | 2681(79.7) |
No | 1117 (22.2) | 682 (20.3) |
Age at first live birth in years, n | 3711 | 2579 |
Mean (SD), y | 25.3 (4.9) | 25.3 (4.9) |
Menopausal status, n (%) | ||
Premenopausal | 2330 (47.4) | 1610 (46.4) |
Postmenopausal | 2588 (52.6) | 1858 (53.6) |
Age at menopause, mean (SD), y | 44.7 (6.0) | 45.6 (6.0) |
*BMI = body mass index; CIMBA = Consortium of Investigators of Modifiers of BRCA1/2; IQR = interquartile range.