Table 2.
Association of height and breast cancer risk using observed height, among 7657 participants
| N/events | HR (95% CI) | P* | |
|---|---|---|---|
| Per 10-cm increase in observed height | |||
| All participants (confounding adjustment sequentially) | |||
| Unadjusted | 7657/3653 | 1.14 (1.06 to 1.22) | 2.0 × 10-4 |
| Adjusted for principal components | 7657/3653 | 1.15 (1.07 to 1.23) | 1.6 × 10-4 |
| Additionally adjusted for country | 7657/3653 | 1.17 (1.09 to 1.26) | 1.3 × 10-4 |
| Additionally adjusted for birth cohort | 7657/3653 | 1.09 (1.01 to 1.17) | .02 |
| Additionally adjusted for mutation status | 7657/3653 | 1.09 (1.02 to 1.17) | .01 |
| Additionally adjusted for menopausal status | 7657/3653 | 1.09 (1.02 to 1.17) | .02 |
| Additionally adjusted for parity and age at menarche | 7090/3383 | 1.10 (1.02 to 1.18) | .01 |
| By mutation status† | |||
| BRCA1 carrier | 4502/2154 | 1.06 (0.97 to 1.16) | .19 |
| BRCA2 carrier | 3155/1499 | 1.17 (1.04 to 1.31) | .007 |
| Pinteraction | .18 | ||
| By menopausal status‡ | |||
| Premenopausal | 7657/2197 | 1.10 (1.01 to 1.20) | .03 |
| Postmenopausal | 3076/1402 | 1.07 (0.95 to 1.19) | .26 |
| Pinteraction‡ | .64 | ||
*
P values were calculated from weighted Cox models. All P values are two-sided. HR = hazard ratio; CI = confidence interval.
†
Adjusted for principal components, birth cohort, country of enrollment, and menopausal status.
‡
Adjusted for principal components, mutation status, birth cohort, and country of enrollment.