Table 3.
Variable | Number of participants | Summary effect | SE | P† | % variation explained |
---|---|---|---|---|---|
Measured height, cm | |||||
All participants | 7657 | 1.012 | 0.029 | 7.0 × 10−241 | 13.4 |
BRCA1 carriers | 4502 | 1.025 | 0.038 | 3.8 × 10−149 | 14.0 |
BRCA2 carriers | 3155 | 0.996 | 0.047 | 2.5 × 10−94 | 12.6 |
Case participants | 3653 | 1.028 | 0.041 | 2.6 × 10−128 | 14.7 |
Control participants | 4004 | 1.000 | 0.042 | 1.1 × 10−116 | 12.3 |
Traditional risk factors | |||||
BMI, kg/m2 | 7516 | −0.010 | 0.024 | .66 | – |
Weight, kg | 7569 | 0.813 | 0.065 | 2.7 × 10−35 | – |
Age at baseline, y | 8578 | 0.123 | 0.036 | 7.3 × 10−4 | – |
Age at menarche, y | 7459 | 0.028 | 0.007 | 9.3 × 10−5 | – |
Parous, yes vs no | 8394 | −0.010 | 0.011 | .35 | – |
Age at first live birth, y | 6290 | −0.014 | 0.025 | .58 | – |
Menopausal status, pre vs post | 8386 | 0.011 | 0.009 | .20 | – |
Age at menopause, y | 4336 | −0.082 | 0.037 | .03 | – |
Regression coefficient is presented for continuous variables and natural log-scale odds ratio for binary variables, per unit increase of the H-GS. BMI = body mass index; SE = standard error.
P values were calculated from linear regression models for all variables except for parity and menopausal status (logistic regression models). All P values are two-sided.