Table 3.

Associations of the height genetic score (height-GS) with height and traditional breast cancer risk factors^*

Variable	Number of participants	Summary effect	SE	P†	% variation explained
Measured height, cm
All participants	7657	1.012	0.029	7.0 × 10−241	13.4
BRCA1 carriers	4502	1.025	0.038	3.8 × 10−149	14.0
BRCA2 carriers	3155	0.996	0.047	2.5 × 10−94	12.6
Case participants	3653	1.028	0.041	2.6 × 10−128	14.7
Control participants	4004	1.000	0.042	1.1 × 10−116	12.3
Traditional risk factors
BMI, kg/m2	7516	−0.010	0.024	.66	–
Weight, kg	7569	0.813	0.065	2.7 × 10−35	–
Age at baseline, y	8578	0.123	0.036	7.3 × 10−4	–
Age at menarche, y	7459	0.028	0.007	9.3 × 10−5	–
Parous, yes vs no	8394	−0.010	0.011	.35	–
Age at first live birth, y	6290	−0.014	0.025	.58	–
Menopausal status, pre vs post	8386	0.011	0.009	.20	–
Age at menopause, y	4336	−0.082	0.037	.03	–

^*Regression coefficient is presented for continuous variables and natural log-scale odds ratio for binary variables, per unit increase of the H-GS. BMI = body mass index; SE = standard error.

^†P values were calculated from linear regression models for all variables except for parity and menopausal status (logistic regression models). All P values are two-sided.