Table 2B.
The association of PAM50 subtypes and risk of relapse with proliferation and tumor size weighted (ROR-PT) scores with distant recurrence-free survival within 5 and 10 years in the Nurses’ Health Study (NHS)/NHSII cohorts.
| 5-years | 10-years | |||||||
|---|---|---|---|---|---|---|---|---|
| Event n/ Total n | HR | (95% CI) | P-Value | Event n/ Total n | HR | (95% CI) | P-Value | |
| A. Crude | ||||||||
| Luminal A | 17/402 | 1.00 | ref | - | 25/402 | 1.00 | ref | - |
| Luminal B | 9/157 | 1.38 | (0.61,3.09) | 0.44 | 18/157 | 1.88 | (1.03,3.45) | 0.04 |
| HER2-enriched | 16/122 | 3.29 | (1.66,6.51) | <0.01 | 18/122 | 2.52 | (1.38,4.62) | <0.01 |
| Basal-like | 9/127 | 1.72 | (0.77,3.86) | 0.19 | 15/127 | 1.95 | (1.03,3.69) | 0.04 |
| Normal-like | 6/68 | 2.14 | (0.84,5.43) | 0.11 | 9/68 | 2.17 | (1.02,4.66) | <0.05 |
| ROR-PT score* | 57/857 | 1.29 | (1.14,1.46) | <0.01 | 85/857 | 1.23 | (1.11,1.36) | <0.01 |
| B. Adjusted Model# | ||||||||
| Luminal A | 17/402 | 1.00 | ref | - | 25/402 | 1.00 | ref | - |
| Luminal B | 9/157 | 1.19 | (0.51,2.79) | 0.69 | 18/157 | 1.68 | (0.88,3.18) | 0.11 |
| HER2-enriched | 16/122 | 2.74 | (1.31,5.70) | <0.01 | 18/122 | 2.18 | (1.15,4.14) | 0.02 |
| Basal-like | 9/127 | 1.96 | (0.76,5.04) | 0.16 | 15/127 | 2.07 | (0.98,4.37) | 0.06 |
| Normal-like | 6/68 | 1.85 | (0.66,5.16) | 0.24 | 9/68 | 1.93 | (0.86,4.34) | 0.11 |
| ROR-PT score* | 57/857 | 1.15 | (0.98,1.34) | 0.08 | 85/857 | 1.10 | (0.97,1.23) | 0.13 |
*
ROR-PT was evaluated as continuous variable per 10-unit change in 857 women with ROR-PT scores.
#
Adjusted model included age and year of diagnosis, clinical grade, stage, type of surgery and type of treatment. Hazard Ratio, HR.