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. 2019 Feb 12;10(4):744–750. doi: 10.1111/1759-7714.12992

Figure 3.

Figure 3

MiR‐98 restrains the level of WNT1 by directly targeting the 3′ untranslated region (3′UTR) of messenger RNAs (mRNAs). (a) Prediction of the targeting of miR‐98 on WNT1 by Targetscan online software. (b) Construction of wild‐type (wt) or mutant (mut) vectors containing binding sites of miR‐98 with 3′UTR of WNT1 mRNA. (c,d) Analysis of miR‐98 (or its inhibitor)‐regulated WNT1 in an A549 cell line by luciferase reporter gene assay. (e) Effect of anti‐miR‐98 and/or aspirin (ASA) on WNT1 3′UTR vector in A549 cell line by luciferase reporter gene assay. *** P < 0.001; ** P < 0.01; ns, not significant.