Table 3.
HRs and 95% CIs of the 30‐year analysis of the association between tooth loss and UGI cancer mortality stratified by age and gender in the dysplasia population trial cohort, Linxian
| Characteristic | UGI cancer† | ESCC | GNCC | GCC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | HR (95% CI) | P interaction | N | HR (95% CI) | P interaction | N | HR (95% CI) | P interaction | N | HR (95% CI) | P interaction | |||
| Age | < 55 years | Moderate | 151 | 1.52 (1.13–2.04) | 0.005 | 95 | 1.53 (1.06–2.05) | 0.021 | 11 | 1.212 (0.442–3.328) | 0.709 | 45 | 1.35 (0.78–2.36) | 0.284 |
| Severe | 215 | 1.26 (0.98–1.63) | 0.071 | 135 | 1.24 (0.90–1.71) | 0.184 | 18 | 3.078 (0.075–8.423) | 0.229 | 62 | 1.26 (0.70–2.24) | 0.443 | ||
| ≥ 55 years | Moderate | 183 | 1.25 (0.84–1.84) | 0.270 | 107 | 1.75 (0.98–3.13) | 0.058 | 14 | 0.451 (0.086–2.378) | 0.348 | 62 | 0.79 (0.43–1.46) | 0.458 | |
| Severe | 222 | 1.17 (0.79–1.74) | 0.437 | 127 | 1.52 (0.84–2.75) | 0.167 | 18 | 0.404 (0.069–2.359) | 0.314 | 77 | 0.83 (0.45–1.53) | 0.556 | ||
| Gender | Men | Moderate | 207 | 1.31 (1.00–1.71) | 0.048 | 117 | 1.52 (1.01–2.28) | 0.044 | 14 | 1.440 (0.511–4.056) | 0.490 | 76 | 1.21 (0.76–1.95) | 0.423 |
| Severe | 168 | 1.24 (0.94–1.63) | 0.129 | 92 | 1.29 (0.89–1.88) | 0.185 | 14 | 1.353 (0.430–4.254) | 0.605 | 62 | 1.37 (0.84–2.23) | 0.209 | ||
| Women | Moderate | 127 | 1.09 (0.75–1.59) | 0.639 | 85 | 1.28 (0.80–2.04) | 0.299 | 11 | 0.549 (0.154–1.958) | 0.355 | 31 | 0.72 (0.31–1.66) | 0.437 | |
| Severe | 269 | 1.07 (0.76–1.51) | 0.690 | 170 | 1.22 (0.79–1.89) | 0.364 | 22 | 1.022 (0.385–2.718) | 0.964 | 77 | 0.62 (0.29–1.33) | 0.222 | ||
| Smoking | Yes | Moderate | 366 | 1.27 (0.90–1.80) | 0.172 | 74 | 1.54 (0.95–2.51) | 0.082 | 5 | 0.500 (0.082–3.048) | 0.452 | 50 | 0.91 (0.51–1.63) | 0.758 |
| Severe | 330 | 1.28 (0.90–1.81) | 0.170 | 67 | 1.46 (0.89–2.40) | 0.138 | 9 | 3.648 (0.750–17.744) | 0.109 | 52 | 1.02 (0.58–1.80) | 0.945 | ||
| No | Moderate | 580 | 1.16 (0.88–1.54) | 0.300 | 128 | 1.20 (0.84–1.70) | 0.320 | 20 | 1.017 (0.407–2.541) | 0.972 | 57 | 1.15 (0.64–2.07) | 0.635 | |
| Severe | 937 | 1.10 (0.84–1.44) | 0.492 | 195 | 1.13 (0.80–1.59) | 0.487 | 27 | 1.141 (0.489–2.661) | 0.760 | 87 | 1.01 (0.55–1.84) | 0.980 | ||
†
Includes esophageal squamous cell carcinoma (ESCC), gastric non‐cardia carcinoma (GNCC), and gastric cardia carcinoma (GCC).
Bold text indicates statistical significance. “N” represents the number of deaths from ESCC, GNCC, GCC, or upper gastrointestinal (UGI) cancer. CI, confidence interval; HR, hazard ratio.