Table 4.
Frequencies of genetics professionals’ ratings of information items as important or very important (n = 57)
| During counselling, you should… | (Very) important | |
|---|---|---|
| n | % | |
| Tumour spectrum | ||
| Explain that several cancers in addition to breast cancer may occur in individuals with LFS | 57 | 100 |
| Provide 1–3 examples of LFS-related cancers | 46 | 81 |
| Mention the four most common tumour types in individuals with LFS | 25 | 44 |
| Mutation detection rate | ||
| Tell that the TP53 mutation detection rate is (very) low | 57 | 100 |
| Specify the TP53 mutation detection rate with a percentage | 19 | 33 |
| Cancer risks | ||
| Explain that individuals with LFS are at high risk of developing cancer | 57 | 100 |
| Explain that individuals with LFS are at increased risk of developing a second cancer | 45 | 79 |
| Explain that individuals with LFS are at increased risk of developing multiple primary cancers | 42 | 74 |
| Specify cancer risk in individuals with LFS with a percentage | 15 | 26 |
| Tell that the overall lifetime cancer risk for women with LFS is higher than that for men | 11 | 19 |
| Other information items | ||
| Discuss possible consequences for family members if a TP53 mutation is detected | 54 | 95 |
| Mention there are limited screening options for TP53 mutation carriers | 53 | 93 |
| Discuss the option of additional support by a psychosocial professional | 51 | 90 |
| Explain that radiotherapy should be avoided in individuals with LFS | 49 | 86 |
| Tell that TP53 mutation carriers are offered a whole-body MRI (within research context) | 47 | 83 |
| Provide examples of possible reasons for or against performing TP53 genetic testing | 40 | 70 |
| Mention the name of genetic disorder | 20 | 35 |
LFS Li–Fraumeni syndrome, MRI magnetic resonance imaging