Table 2.
Multi-variable adjusted hazards ratios for incident PAD in relation to plasma biomarkers.
| Variable | PAD | p |
|---|---|---|
| N = 244 | ||
| HR* (95% CI) | ||
| Plasma inflammatory biomarkers | ||
| CRP (n = 5300) | 1.55 (1.36–1.76) | <0.001 |
| Proneurotensin (n = 4627) | 0.94 (0.80–1.09) | 0.41 |
| Lp-PLAS2 (mass) (n = 5390) | 1.20 (1.05–1.37) | 0.008 |
| Lp-PLAS2 (activity) (n = 5395) | 1.33 (1.17–1.52) | <0.001 |
The following variables were entered in the multivariable analysis besides each respective plasma biomarker:
Age at study entry, sex, body mass index, current smoking, diabetes mellitus, hypertension.
*Hazard ratios (HR) were expressed per one SD increment of each respective log transformed plasma biomarker.
PAD; peripheral artery disease, CRP; C-reactive protein, Lp-PLA2 (activity and mass); lipoprotein-associated phospholipase A2, HR; Hazard Ratio, CI; Confidence interval.