Table 1.
Focal deletion of STK25 is common in human cancers
| Cancer type | Q-value | Frequencies | ||
|---|---|---|---|---|
| Overall | Focal deletion | High-level deletion | ||
| Cervical squamous cell carcinoma | 5.99E−43 | 0.4034 | 0.2814 | 0.0068 |
| Sarcoma | 2.38E−35 | 0.4297 | 0.2734 | 0.0898 |
| Bladder urothelial carcinoma | 6.81E−33 | 0.4297 | 0.2647 | 0.0172 |
| HNSCC | 2.08E−26 | 0.4951 | 0.1935 | 0.0000 |
| Kidney cancers | 1.05E−25 | 0.2989 | 0.0578 | 0.0023 |
| Brain lower grade glioma | 6.16E−24 | 0.1259 | 0.1014 | 0.0039 |
| Lung cancers | 1.82E−22 | 0.1481 | 0.1396 | 0.0000 |
| Lung squamous cell carcinoma | 2.71E−21 | 0.2183 | 0.2136 | 0.0000 |
| Kidney RCC carcinoma | 1.93E−19 | 0.0947 | 0.0701 | 0.0019 |
| Glial cancers | 4.42E−17 | 0.1239 | 0.0670 | 0.0018 |
| Breast invasive adenocarcinoma | 5.75E−16 | 0.2944 | 0.1157 | 0.0019 |
| Ovarian serous cystadenocarcinoma | 3.19E−15 | 0.3040 | 0.2228 | 0.0121 |
| Stomach adenocarcinoma | 4.89E−6 | 0.1633 | 0.1043 | 0.0000 |
| All Cancers | 5.6E−223 | 0.1892 | 0.1050 | 0.0049 |
Publicly available TCGA datasets were probed to assess rates of focal deletion in STK25 using the Tumorscape program online (http://www.broadinstitute.org/tcga/). The top 10 cancers with the highest rates of focal deletions in STK25 are shown, together with the “All Cancers” dataset