Table 2.
Baseline biochemical characteristics of healthy controls and patients of acromegaly.
| Parameters | Group HC Healthy controls (n = 10) MEAN ± S.D. (Mean Rank) |
Group A Acromegaly without Diabetes (n = 10) MEAN ± S.D. (Mean Rank) |
Group B Acromegaly with Diabetes (n = 10) MEAN ± S.D. (Mean Rank) |
Non parametric tests (Kruskal Wallis) Chi square (p value) Post Hoc |
|---|---|---|---|---|
| FPG (mg/dl) | 86.60 ± 06.55 (07.00) |
93.63 ± 03.82 (14.20) |
145.41 ± 49.19 (25.30) |
21.933 (0.0005***) HC < B***, A < B** |
| FPI (µU/ml) | 12.66 ± 04.07 (08.20) |
20.80 ± 05.3 (19.80) |
30.39 ± 23.24 (18.50) |
10.423 (0.005**) HC < A**, HC < B* |
| FCP (ng/ml) | 02.38 ± 0.57 (06.90) |
04.23 ± 0.89 (20.15) |
05.55 ± 03.87 (19.45) |
14.359 (0.001***) HC < A***, HC < B** |
| HOMA-IR | 1.71 ± 0.396 (05.60) |
03.53. ± 01.01 (19.00) |
04.12 ± 01.57 (21.90) |
19.51 (0.0005***) HC < A**, HC < B*** |
| HOMA-IS | 62.08 ± 18.46 (25.40) |
30.20 ± 07.86 (12.00) |
26.72 ± 07.56 (09.10) |
19.51 (0.0005***) HC** > A, HC > B*** |
| Matsuda Index | 3.8 ± 1.6 (24.30) |
1.6 ± 0.5 (11.90) |
1.6 ± 1.3 (10.30) |
15.154 (0.001***) HC** > A, HC > B*** |
| HOMA-β | 153.86 ± 43.84 (14.60) |
213.13 ± 48.76 (23.70) |
11.97 ± 43.85 (08.20) |
15.65 (0.0005***) A*** > B |
| Insulinogenic index | 7.7 ± 5.7 (20.75) |
4.4 ± 4.5 (15.80) |
1.6 ± 1.0 (8.20) |
10.733 (0.0005***) HC** > B |
| Hyperinsulinemic Euglycemic Clamp | ||||
| GDR (mg/kg/min) | — | 2.57 ± 0.84 (13.70) |
1.75 ± 0.62 (07.30) |
18.00 (0.015**) (X) |
| IS (mg/kg/min/uU/ml) | — | 04.48 ± 02.15 (11.00) |
04.06 ± 02.66 (10.00) |
45.00 (0.705) (X) |
FPG - Fasting plasma glucose; FPI - Fasting plasma insulin; FPC - Fasting plasma c-peptide; HOMA-IR- Homeostatic model assessment of insulin resistance; HOMA-β -Homeostatic model assessment of β cell function; HOMA-IS- Homeostatic model assessment of insulin sensitivity; GDR: Glucose disposal rate; and IS- insulin sensitivity. *P < 0.05, **P < 0.01, ***P < 0.001.