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. 2019 Apr 4;10:1535. doi: 10.1038/s41467-019-08949-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — CTCF-s/CTCF competition and transcriptional regulation. a Hierarchical clustering of differentially expressed (DE) gene profiles after overexpression of FLAG-CTCF-s in HeLa-S3 cells. Fold-change was relative to the mean of the FLAG control. b Analysis of CTCF binding at promoters of DE genes, from panel (a). c CTCF-s downregulated genes tended to have decreased CTCF binding at their promoter regions. The center line represents the second quartile, the bounds of box represent third quartile and first quartile. The whiskers indicate 1.5 × interquartile range and dots represent outliers. d Upregulated genes by CTCF-s tended to have enhancers that were closer to the TSS than downregulated genes. The center line represents the second quartile, the bounds of box represent third quartile and first quartile. The whiskers indicate 1.5 × interquartile range and dots represent outliers. The statistical significance for the boxplots in (c, d) was assessed by Wilcoxon rank sum test