Table 2. Stratification analysis for association between H19 genotypes and neuroblastoma susceptibility.
Variables | rs2839698 (patient/control) | Adjusted OR1 | P1 | rs3024270 (patient/control) | Adjusted OR1 | P1 | rs217727 (patient/control) | Adjusted OR1 | P1 | Risk genotypes (patient/control) | Adjusted OR1 | P1 | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG/AG | AA | (95% CI) | CC/CG | GG | (95% CI) | GG/AG | AA | (95% CI) | 0 | 1-3 | (95% CI) | |||||
Age, months | ||||||||||||||||
≤18 | 110/276 | 15/29 | 1.29 (0.66–2.50) | 0.452 | 95/240 | 31/65 | 1.21 (0.74–1.97) | 0.454 | 116/270 | 10/35 | 0.67 (0.32–1.39) | 0.278 | 85/205 | 41/100 | 0.99 (0.64–1.54) | 0.962 |
>18 | 243/462 | 24/43 | 1.06 (0.63–1.79) | 0.830 | 207/397 | 60/108 | 1.07 (0.75–1.52) | 0.727 | 234/454 | 33/51 | 1.25 (0.79–2.00) | 0.342 | 173/346 | 94/159 | 1.18 (0.86–1.62) | 0.297 |
Sex | ||||||||||||||||
Female | 148/317 | 20/24 | 1.79 (0.96–3.34) | 0.068 | 123/278 | 45/63 | 1.61 (1.04–2.50) | 0.032 | 152/302 | 16/39 | 0.83 (0.45–1.53) | 0.546 | 107/239 | 61/102 | 1.35 (0.91–1.99) | 0.137 |
Male | 206/421 | 19/48 | 0.83 (0.48–1.45) | 0.516 | 179/359 | 46/110 | 0.85 (0.57–1.25) | 0.398 | 198/422 | 27/47 | 1.22 (0.74–2.02) | 0.442 | 151/312 | 74/157 | 0.98 (0.70–1.37) | 0.899 |
Sites of origin | ||||||||||||||||
Adrenal gland | 140/738 | 13/72 | 0.97 (0.52–1.80) | 0.915 | 115/637 | 38/173 | 1.23 (0.82–1.84) | 0.327 | 133/724 | 20/86 | 1.24 (0.73–2.08) | 0.430 | 94/551 | 59/259 | 1.33 (0.93–1.90) | 0.122 |
Retroperitoneal | 79/738 | 8/72 | 1.01 (0.47–2.18) | 0.982 | 67/637 | 20/173 | 1.08 (0.64–1.83) | 0.776 | 82/724 | 5/86 | 0.52 (0.21–1.32) | 0.169 | 62/551 | 25/259 | 0.85 (0.52–1.39) | 0.516 |
Mediastinum | 98/738 | 11/72 | 1.16 (0.59–2.27) | 0.661 | 89/637 | 20/173 | 0.84 (0.50–1.40) | 0.493 | 95/724 | 14/86 | 1.25 (0.68–2.28) | 0.478 | 75/551 | 34/259 | 0.97 (0.63–1.50) | 0.901 |
Others | 30/738 | 6/72 | 2.00 (0.81–4.99) | 0.135 | 24/637 | 12/173 | 1.82 (0.89–3.73) | 0.100 | 34/724 | 2/86 | 0.50 (0.12–2.13) | 0.350 | 22/551 | 14/259 | 1.35 (0.68–2.69) | 0.391 |
Clinical stage | ||||||||||||||||
I+II+4s | 146/738 | 16/72 | 1.13 (0.64–2.00) | 0.677 | 126/637 | 36/173 | 1.06 (0.70–1.59) | 0.792 | 143/724 | 19/86 | 1.13 (0.66–1.91) | 0.661 | 107/551 | 55/259 | 1.10 (0.77–1.57) | 0.602 |
III+IV | 190/738 | 21/72 | 1.17 (0.70–1.95) | 0.561 | 160/637 | 51/173 | 1.19 (0.83–1.71) | 0.335 | 187/724 | 24/86 | 1.06 (0.65–1.71) | 0.821 | 135/551 | 76/259 | 1.20 (0.87–1.65) | 0.259 |
Adjusted for age and sex.
Values in bold inidicate P<0.05.