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. 2019 Apr 5;39(4):BSR20181582. doi: 10.1042/BSR20181582

Table 2. Stratification analysis for association between H19 genotypes and neuroblastoma susceptibility.

Variables rs2839698 (patient/control) Adjusted OR1 P1 rs3024270 (patient/control) Adjusted OR1 P1 rs217727 (patient/control) Adjusted OR1 P1 Risk genotypes (patient/control) Adjusted OR1 P1
GG/AG AA (95% CI) CC/CG GG (95% CI) GG/AG AA (95% CI) 0 1-3 (95% CI)
Age, months
≤18 110/276 15/29 1.29 (0.66–2.50) 0.452 95/240 31/65 1.21 (0.74–1.97) 0.454 116/270 10/35 0.67 (0.32–1.39) 0.278 85/205 41/100 0.99 (0.64–1.54) 0.962
>18 243/462 24/43 1.06 (0.63–1.79) 0.830 207/397 60/108 1.07 (0.75–1.52) 0.727 234/454 33/51 1.25 (0.79–2.00) 0.342 173/346 94/159 1.18 (0.86–1.62) 0.297
Sex
Female 148/317 20/24 1.79 (0.96–3.34) 0.068 123/278 45/63 1.61 (1.04–2.50) 0.032 152/302 16/39 0.83 (0.45–1.53) 0.546 107/239 61/102 1.35 (0.91–1.99) 0.137
Male 206/421 19/48 0.83 (0.48–1.45) 0.516 179/359 46/110 0.85 (0.57–1.25) 0.398 198/422 27/47 1.22 (0.74–2.02) 0.442 151/312 74/157 0.98 (0.70–1.37) 0.899
Sites of origin
Adrenal gland 140/738 13/72 0.97 (0.52–1.80) 0.915 115/637 38/173 1.23 (0.82–1.84) 0.327 133/724 20/86 1.24 (0.73–2.08) 0.430 94/551 59/259 1.33 (0.93–1.90) 0.122
Retroperitoneal 79/738 8/72 1.01 (0.47–2.18) 0.982 67/637 20/173 1.08 (0.64–1.83) 0.776 82/724 5/86 0.52 (0.21–1.32) 0.169 62/551 25/259 0.85 (0.52–1.39) 0.516
Mediastinum 98/738 11/72 1.16 (0.59–2.27) 0.661 89/637 20/173 0.84 (0.50–1.40) 0.493 95/724 14/86 1.25 (0.68–2.28) 0.478 75/551 34/259 0.97 (0.63–1.50) 0.901
Others 30/738 6/72 2.00 (0.81–4.99) 0.135 24/637 12/173 1.82 (0.89–3.73) 0.100 34/724 2/86 0.50 (0.12–2.13) 0.350 22/551 14/259 1.35 (0.68–2.69) 0.391
Clinical stage
I+II+4s 146/738 16/72 1.13 (0.64–2.00) 0.677 126/637 36/173 1.06 (0.70–1.59) 0.792 143/724 19/86 1.13 (0.66–1.91) 0.661 107/551 55/259 1.10 (0.77–1.57) 0.602
III+IV 190/738 21/72 1.17 (0.70–1.95) 0.561 160/637 51/173 1.19 (0.83–1.71) 0.335 187/724 24/86 1.06 (0.65–1.71) 0.821 135/551 76/259 1.20 (0.87–1.65) 0.259
1

Adjusted for age and sex.

Values in bold inidicate P<0.05.