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. 2019 Apr 5;39(4):BSR20190072. doi: 10.1042/BSR20190072

Figure 3. Microglial lipid profile is distinctly remodeled by oleate, palmitate, and LPS treatment.

Figure 3

BV2 cells were treated for 24 h with 0.25% (37.8 µM) BSA, 200 µM oleate, 200 µM palmitate, or 1 µg/ml LPS followed by lipid extraction and lipidomic analysis. (A) Heat-map presenting top 75 altered lipids (according to their P-values). Each row corresponds to a lipid where the detection level in each sample was normalized by the average detection in all samples. The complete data of significantly altered lipid molecular species is displayed in Supplementary Table S2. (B) PCA. Total log-normalized lipid concentrations used to depict the scatter plots of first and the second principal components (PC1 and PC2, respectively). Abbreviations: OA, oleate; PA, palmitate.