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. 2019 Apr 5;39(4):BSR20190072. doi: 10.1042/BSR20190072

Figure 4. Major lipid classes are modulated during microglial reprogramming.

Figure 4

BV2 cells were treated for 24 h with 0.25% (37.8 µM) BSA, 200 µM oleate, 200 µM palmitate or 1 µg/ml LPS followed by lipid extraction and lipidomic analysis. (A–D) Microglial lipidome represented by 11 lipid classes detected by lipidomic analysis. (E) CD36 gene expression. Values represent averages ± SEM from five (E) or six (A–D) independent experiments and were compared using one-way ANOVA followed by Tukey’s post test. *P<0.05 vs BSA. #P<0.05 vs LPS. $P<0.05 vs OA. Q-9+10 values cannot be taken as absolute concentrations, see Supplementary Table S1 for CoQ quantification.

Abbreviations: Cer, ceramide; CL, cardiolipin; PC, phosphatidylcholine; PDME, phosphatidyldimethylethanolamine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; Q-9+10, Coenzymes Q9 + Q10; SM, sphingomyelin.