Table 1.
Summary of AUC:MIC ratio targets for S. pneumoniae and S. aureus efficacy
| Pathogen | Bacterial reduction endpoint (log10 cfu reduction from baseline) | Median AUC:MIC ratio targeta |
|
|---|---|---|---|
| total-drug ELF | free-drug plasma | ||
| S. pneumoniae | 1 | 14.0 | 1.37 |
| 2 | 22.0 | 2.15 | |
| S. aureus | 1 | 21.7 | 2.13 |
| 2 | 63.9 | 6.24 | |
a
Median AUC:MIC ratio targets were determined based on the evaluation of data for five S. pneumoniae and five S. aureus isolates using a neutropenic murine lung infection model described in this Supplement (see ‘Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae’22).