Table 2.

Summary statistics for day 1 AUC_0–24 values among simulated patients after administration of lefamulin iv and oral dosing regimens

Lefamulin dosing regimen (mg)	Route of administration	Food status	Exposure matrix	Mean (%CV)	Median (range)
150	iv	fasted	total-drug plasma	13.2 (13.5)	13.1 (8.76–19.5)
			free-drug plasma	1.67 (13.9)	1.65 (1.06–2.45)
			total-drug ELF	9.46 (47.6)	8.58 (2.06–33.4)
600	oral	fasted	total-drug plasma	13.4 (19.6)	13.3 (6.49–23.6)
			free-drug plasma	1.59 (22.2)	1.56 (0.69–3.04)
			total-drug ELF	8.92 (49.6)	8.00 (1.20–40.9)
		fed	total-drug plasma	10.1 (23.1)	9.94 (4.13–18.3)
			free-drug plasma	1.12 (25.5)	1.10 (0.42–2.17)
			total-drug ELF	6.07 (51.4)	5.38 (0.788–28.0)