Table 3.

Overall percentage probabilities of PK/PD target attainment for lefamulin dosing regimens based on the evaluation of total-drug ELF or free-drug plasma AUC:MIC ratio targets associated with a 1 log₁₀ cfu reduction from baseline for S. pneumoniae and S. aureus

Pathogen	Exposure matrix	Overall percentage probabilities of PK/PD target attainmenta
		iv	oral
			fed	fasted
S. pneumoniae	total-drug ELF	99.6	98.3	99.5
	free-drug plasma	100	99.9	100
S. aureus	total-drug ELF	99.5	98.5	99.4
	free-drug plasma	99.7	99.7	99.7

^aBased on the MIC distributions for S. pneumoniae or S. aureus isolates collected as part of the 2015–16 SENTRY Antimicrobial Surveillance Program from global regions.