Table 3.

Lefamulin and daptomycin MIC values in the presence of increasing lung surfactant concentrations

		Test organism MIC (mg/L)
Surfactant concentration		S. pneumoniae			S. aureus
mg/L	% (v/v)	248092 (n = 4)	411627 (n = 4)	ATCC 49619 (n = 2)	ATCC 33591 (n = 2)	ATCC 29213 (n = 3)
Lefamulin
0	0	0.06–0.12	0.03–0.06	0.03–0.06	0.06–0.12	0.12
15	0.06	0.06–0.12	0.03–0.06	0.03–0.06	0.06–0.12	0.06–0.12
31	0.12	0.06–0.12	0.03–0.06	0.03–0.06	0.06–0.12	0.12
62.5	0.25	0.06–0.12	0.03–0.06	0.03–0.06	0.06–0.12	0.06–0.12
125	0.5	0.06–0.25	0.03–0.06	0.06	0.06–0.12	0.12
250	1	0.06–0.12	0.03–0.06	0.06	0.12	0.12
500	2	ND	ND	ND	0.12–0.25	0.12–0.25
1000	4	ND	ND	ND	0.12–0.25	0.12–0.25
Daptomycin
0	0	0.12–0.25	0.06–0.25	0.06	0.25–1	0.5–1
15	0.06	0.25–0.5	0.25–0.5	0.25–0.5	2	1–2
31	0.12	0.5–1	0.25–2	0.25–1	4	2–4
62.5	0.25	1–2	0.5–2	0.5–1	8	8
125	0.5	2–8	1–4	1–4	8–16	16
250	1	4–16	1–8	2–16	>16	>16
500	2	8–>16	2–>16	4–>16	>16	>16
1000	4	>16	2–>16	2–>16	>16	>16

ND, not determined.