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Plasma and ELF exposure measures following a single subcutaneous lefamulin dosea
| Dose (mg/kg) | Matrix | Cmax (mg/L) | AUC0–24 (mg·h/L) | AUC0–24 (mg·h/L)/dose (mg/kg) |
|---|---|---|---|---|
| 35 | plasma | 1.74 | 5.13 | 0.147 |
| ELF | 2.47 | 10.7 | 0.305 | |
| 70 | plasma | 2.46 | 8.66 | 0.124 |
| ELF | 2.96 | 17.6 | 0.251 |
Mean values of the dose-normalized AUC0–24 for plasma (0.136 mg·h/L per mg/kg) and ELF (0.278 mg·h/L per mg/kg) were used for the translation of dose to exposure.
