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. 2019 Mar 29;10:277. doi: 10.3389/fgene.2019.00277

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Copyright © 2019 Han, Ren, Cao, Zhao and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the H3K4me3-increased region that were enriched in the proximal promoter region (≤1 kb) of up-regulated genes (A) genome-wide distribution of the increased signals of H3K4me3 that were found to be enriched in up-regulated genes (1,869 genes). (B) Box plot of rld expression value of genes that were up-regulated and affected by H3K4me3. ^∗∗∗P < 0.001 (C) Gene ontology analysis of the up-regulated genes that were associated with the increase of H3K4me3 in the proximal promoter region (≤1 kb). GD50, day 50 of gestation; GD95, day 95 of gestation.