Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Co-stimulatory and inhibitory receptors of the immunoglobulin superfamily and TNFR family.
| Inhibitory molecules | Co-stimulatory molecules | ||||
|---|---|---|---|---|---|
| Family | Molecule | Ligand | Family | Molecule | Ligand |
| IgSF | PD-1 | PDL1 | IgSF | CD28 | CD80 |
| PDL2 | CD86 | ||||
| CTLA-4 | CD80 | ICOS | ICOSL | ||
| CD8 | TNFRSF | HVEM | BTLA | ||
| BTLA | HVEM | LIGHT | |||
| Tim3 | Galectin-9 | 4-1BB | 4-1BBL | ||
| TIGIT | PVR | OX40 | OX40L | ||
| CD155 | CD27 | CD70 | |||
| CD112 | CD30 | CD30L | |||
| Lag3 | MHCII | CD40 | CD40L | ||
| CD160 | HVEM | GITR | GITRL | ||
