Figure 1. Highlights of the effects of soy isoflavones application along the sequence of events relevant to metastasis formation in prostate cancer (sorted in a clockwise direction; references are provided in the appropriate section of the article). ARs - androgen receptors, EMT - epithelial to mesenchymal transition, FAK - focal adhesion kinase, MET - mesenchymal to epithelial transition, MMPs - matrix metalloproteinases, OPG - osteoprotegerin, PSA - prostate-specific antigen, PTHrP - parathyroid hormone-related protein, RANKL - receptor activator of nuclear factor-κB ligand, uPA - urokinase-type plasminogen activator, VEGF - vascular endothelial growth factor.
