Fig. 5. Restorative effect afforded by ATM inhibition on DNA DSBs and nuclear size in senescent WS fibroblasts.

(A) Neutral comet assay to measure tail moment (A) and head area (B) in WS fibroblasts (**P < 0.01, n.s.: not significant, one-way ANOVA followed by Bonferroni’s multiple comparison test). Means ± S.D., N = 100. Cells were treated with DMSO or 0.5 μM KU-60019 for 14 days.