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. 2019 Apr 4;12(6):801–809. doi: 10.1016/j.tranon.2019.02.016

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

In vivo effect of HHT and IPI504 combination. (A, B) The trend of bioluminescence intensities and xenogen images of NSG mice transplanted with luciferase-labeled MOLM-13 cells before (day 14) and after treatment with vehicle (n = 6), HHT (n = 6), IPI504 (n = 6), and their combination (n = 6). (C) The change of body weight of mice treated with vehicle, HHT, IPI504 and combination of both. (D) Kaplan-Meier survival curves were analyzed for the mice and Log-rank test was used to calculate the statistical significances with HHT compared to vehicle (P - .004), IPI504 compared to vehicle (P - .017) and HHT+IPI504 compared to vehicle (P - .001), respectively.