Table 1.
Predicted functions of the main new members of aromatic regulons.
| COG or other ID | Predicted function | Regulated by TFs |
|---|---|---|
| COG115 | 4-Amino-4-deoxychorismate lyase | AphR |
| COG183 | β-ketoadipyl -CoA thiolase | TfdR(S) |
| COG251 | Enamine deaminase involved in utilization of benzoate derivative and stress resistance | CatM/BenM, BoxR |
| COG318 | β-ketoadipyl -CoA synthetase, involved in the lower 2,4-D metabolism | TfdR(S) |
| COG1012 | Benzaldehyde dehydrogenase | CatM/BenM |
| COG1024 | Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase, possibly involved in the conversion of 2,3-didehydroadipyl-CoA to 3-ketoadipyl-CoA | TfdR(S) |
| COG1024/ COG447 | 3-Hydroxyacyl-CoA hydro-lyase | BoxR |
| COG1062 | Benzyl-alcohol dehydrogenase | CatM/BenM |
| COG1250 | 3-Hydroxyadipyl-CoA dehydrogenase | BoxR |
| COG1545 | Distantly related to acyl dehydratases, functionally connected to β-ketoadipyl-CoA thiolase | TfdR(S) |
| COG1894, COG3383 | Formate dehydrogenase possibly involved in the oxidation of formate generated by BoxC | BoxR |
| COG2271 | Hydroxybenzoate or some benzoate-related compound transporter | CatM/BenM |
| COG3181 | Aromatic transporter family receptor | AphS, AphR, AphT, ClcR, CatR(M)/BenM, CatR∗ |
| COG3246 | 3-Keto acid (possibly, β-ketoadipate) cleavage enzyme involved in the catechol metabolism | CatM/BenM |
| COG3485 | Dioxygenase of some catechol derivative, possibly 3,4-dihydroxybenzoate or 3,4-dihydroxyphenylacetate | AphT |
| COG3945 | Protein with hemerythrin/HHE cation-binding motif, possibly protecting the cell from toxic compounds and/or acting as an oxygen store/scavenger | AphS, BenR, BoxR |
| COG3971 | 2-Oxo-hepta-3-ene-1,7-dioic acid hydratase | AphT |
| COG4231 | 2-Ketoacid ferredoxin oxidoreductase, distantly homologous to arylpyruvate ferredoxin oxidoreductases | AphS, BenR |
| COG4447, COG1033, PF07044, DUF1302 | Proteins possibly involved in coping with toxic concentrations of aromatic compounds and with the solvent-stress response | AphS, AphR, AphT |