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. 2019 Mar 29;13:280. doi: 10.3389/fnins.2019.00280

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Copyright © 2019 Engineer, Kimberley, Prudente, Dawson, Tarver and Hays.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vagus Nerve Stimulation therapy improves recovery in a variety of models of neurological injury. A meta-analysis of recovery across a range of rat models of neurological damage demonstrates that VNS paired with rehabilitative training (VNS+Rehab) consistently improves recovery of forelimb motor function compared to equivalent rehabilitative training without VNS (Rehab Alone). The data are presented as a forest plot. Markers denote standardized mean difference for VNS+Rehab compared to Rehab Alone for each study, and horizontal lines indicate 95% confidence interval. The size of the indicator represents the number of subjects. The blue diamond represents the summary effect.