Table II.
Univariate and multivariate analyses of independent factors for disease-specific survival.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| A, Pathological parameters | HR | P-value | HR | 95% CI | P-value | |
| Age (≥71 or <71 years) | 1.502 | 0.165 | ||||
| Sex (men or women) | 0.832 | 0.569 | ||||
| Urine cytology (positive or negative) | 1.971 | 0.034 | 1.479 | 0.679 | 3.398 | 0.330 |
| Tumor histology (UC alone or with other component) | 2.895 | 0.002 | 1.371 | 0.514 | 3.380 | 0.514 |
| Pathological T stage (≥T3 or ≤T2) | 4.686 | <0.001 | 1.853 | 0.750 | 4.835 | 0.183 |
| Tumor grade (high or PUNLMP/low) | 5.056 | <0.001 | 1.824 | 0.643 | 6.025 | 0.268 |
| Lymph node metastasis (positive or negative) | 5.066 | <0.001 | 1.021 | 0.300 | 3.150 | 0.972 |
| Ureter involvement (positive or negative) | 1.329 | 0.339 | ||||
| Surgical margins (positive or negative) | 2.904 | 0.004 | 2.401 | 1.044 | 5.255 | 0.040 |
| Lymphovascular invasion (positive or negative) | 7.029 | <0.001 | 2.366 | 0.920 | 6.376 | 0.074 |
| History of bladder cancer (present or absent) | 1.046 | 0.893 | ||||
| Carcinoma in situ (positive or negative) | 0.676 | 0.429 | ||||
| Hydronephrosis (positive or negative) | 1.657 | 0.109 | ||||
| Surgical procedure (open or laparoscopic) | 1.463 | 0.209 | ||||
| Univariate | Multivariate | |||||
| B, Clinical parameters | HR | P-value | HR | P-value | P-value | |
| Preoperative eGFR (<60 or ≥60) | 3.259 | <0.001 | 2.371 | 1.024 | 5.898 | 0.044 |
| Preoperative CAR (≥0.079 or <0.079) | 2.528 | 0.002 | 1.343 | 0.523 | 3.446 | 0.538 |
| Preoperative NLR (≥2.035 or <2.035) | 2.371 | 0.009 | 1.598 | 0.643 | 4.268 | 0.318 |
| Preoperative PLR (≥165 or <165) | 2.200 | 0.008 | 0.964 | 0.463 | 2.011 | 0.922 |
| Preoperative GPS (≥1 or 0) | 3.088 | 0.003 | 0.985 | 0.303 | 2.941 | 0.979 |
| Fibrinogen (≥337 or <337) | 4.199 | <0.001 | 1.632 | 0.618 | 4.240 | 0.321 |
HR, hazard ratio; CI, confidence interval; UC, urothelial carcinoma; CIS, carcinoma in situ; PUNLMP, papillary urothelial neoplasm of low malignant potential; eGFR, estimated glomerular filtration rate (ml/min/1.73 m2); CAR, C-reactive protein to albumin ratio; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; GPS, Glasgow prognostic score.