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. 2019 Apr 4;17:111. doi: 10.1186/s12967-019-1845-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of TSP4-BMSCs on HUVEC angiogenesis. a–c VEGF, TGFβ and TSP4 level in the supernatant of HUVECs incubated with BMSCs was detected by ELISA. Data are expressed as the mean ± SD. **p < 0.01. d, e Effect of TSP4-BMSCs on the proliferation and migration of HUVECs at 24 h and 48 h by wound healing test. Data are expressed as the mean ± SD. **p < 0.01, *p < 0.05. f, g Effect of TSP4-BMSCs on HUVEC tube formation at 48 h. Data are expressed as the mean ± SD. **p < 0.01. h, i The effect of TSP4-BMSCs on angiogenesis was examined by arterial ring experiment. Data are expressed as the mean ± SD. **p < 0.01